Striking the Right Balance: Cortical Modulation of the Subthalamic Nucleus-Globus Pallidus Circuit
نویسندگان
چکیده
The subthalamic nucleus-globus pallidus network is a potential source of oscillations in Parkinson's disease, but the mechanism is unknown. In this issue of Neuron, Chu et al. (2015) present a cortically driven form of heterosynaptic plasticity that could promote oscillatory activity after dopamine depletion.
منابع مشابه
Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network.
The subthalamic nucleus-globus pallidus network plays a central role in basal ganglia function and dysfunction. To determine whether the relationship between activity in this network and the principal afferent of the basal ganglia, the cortex, is altered in a model of Parkinson's disease, we recorded unit activity in the subthalamic nucleus-globus pallidus network together with cortical electro...
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The two principal movement-suppressing pathways of the basal ganglia, the so-called hyperdirect and indirect pathways, interact within the subthalamic nucleus (STN). An appropriate level and pattern of hyperdirect pathway cortical excitation and indirect pathway external globus pallidus (GPe) inhibition of the STN are critical for normal movement and are greatly perturbed in Parkinson's disease...
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عنوان ژورنال:
- Neuron
دوره 85 شماره
صفحات -
تاریخ انتشار 2015